The Role of Peripheral Blood Inflammatory Markers in the Staging of Breast Cancer

INTRODUCTION: This study aims to evaluate the importance of neutrophil-lymphocyte ratio (NLR), lymphocyte-monocyte ratio (LMR), platelet-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) in the staging of breast cancer.
METHODS: One-hundred patients with breast cancer between January 2005 and December 2019 were reviewed retrospectively. Clinical and demographic data of patients were reviewed from the hospital records. Age, gender, pre-treatment complete blood count results and stages were analyzed from patient files.
RESULTS: The median NLR, PLR, and SII values of the T3 stage were higher than the T1 and T2 stages. While there was no difference between the groups according to the N stage, a difference was found between the peripheral blood inflammatory markers of Stage I, II, and III groups. The median NLR, PLR, and SII values of stage III were higher than the stage II and III.
DISCUSSION AND CONCLUSION: As a result, NLR, PLR, LMR, and SII may be valuable in breast cancer staging.