ISSN 1301 - 0883 | E-ISSN: 2687-5101
Eastern Journal of Medicine
Acute leucoencephalopathy with restriction of diffusion-a case report [Eastern J Med]
Eastern J Med. 2012; 17(3): 149-152

Acute leucoencephalopathy with restriction of diffusion-a case report

Vivek Singh1, Vaishali Tomar1, Alok Kumar1, Rajendra V. Phadke1

Acute white matter insult in a non traumatic, non ischemic background has been recently identified in certain clinical situations. Named toxic leukoencephalopathy, it may be caused by exposure to a wide variety of agents, including cranial irradiation, therapeutic agents, drugs of abuse, and environmental toxins. Extensive central white matter restriction of diffusion in the absence of significant T2 or Fluid-attenuated inversion recovery (FLAIR) abnormality is the imaging hallmark on Magnetic Resonance Imaging (MRI). Reversibility of the symptoms after the withdrawal of toxin has been shown in a few reports. We present one such case with reversal of changes on MRI and clinical improvement.

Keywords: ADEM, intramyelinic edema, PRES, toxic leukoencephalopathy

Vivek Singh, Vaishali Tomar, Alok Kumar, Rajendra V. Phadke. Acute leucoencephalopathy with restriction of diffusion-a case report. Eastern J Med. 2012; 17(3): 149-152
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