The Effect of Short v.s Long -Term Antibiotic Prophylaxis in Gynecologic Surgery

INTRODUCTION: This study aimed to investigate the difference between the prophylaxis made with only one or two dose first-generation cephalosporin and at least 3 days first-generation cephalosporin use in the emergence of surgical site infections in patients with vertical abdominal incision.
METHODS: This study was completed retrospectively by examining the file, computer and laboratory results of 91 postoperative patients with median incision who showed a high risk for infection in Haseki Training and Research Hospital Department of Obstetrics and Gynecology between August 2014-May 2015.
RESULTS: In our study, surgical site infection in the short-term perioperative prophylaxis group is 57,1 percent of patients, while in long-term perioperative prophylaxis group this rate is 15,4 percent. In short-term perioperative prophylaxis group, surgical site infections rate were detected significantly higher p (<0,001) than long-term perioperative prophylaxis group.
DISCUSSION AND CONCLUSION: In our study, perioperative prophylaxis with only one or two doses of Cefazolin Na in gynecological or gyneco-oncological operations with median incision, contrary to what was suggested by the guide, were found to be significantly inadequate p (<0,001) versus to the at least three days prophylaxis with Cefazolin Na in the prevention of surgical site infections. However, it was found that perioperative prophylaxis of at least 3 days was sufficient.