ISSN 1301 - 0883 | E-ISSN: 2687-5101
Eastern Journal of Medicine
The Prognostic Role of AB0 Blood Groups In Pancreas Cancer [Eastern J Med]
Eastern J Med. 2021; 26(2): 224-227 | DOI: 10.5505/ejm.2021.03360

The Prognostic Role of AB0 Blood Groups In Pancreas Cancer

Sema Turker1, Ebru Cilbir1, Deniz Can Güven2, Hayriye Şahinli1, Cengiz Karaçin1, Şuayib Yalçın2
1Medical Oncology, Diskapi Training and Research Hospital, Ankara, Turkey.
2Department of Medical Oncology, Hacettepe University Cancer Institute, Ankara, Turkey.

INTRODUCTION: Previous studies have reported the relationship between the risk of developing pancreatic cancer and blood groups. There have been conflicting results with respect to the prognostic significance of the AB0 blood group in pancreas cancer. We aimed to evaluate the impacts of blood groups on prognosis in our pancreatic cancer patient population.
METHODS: Patients diagnosed with pancreas cancer between January 2014 and December 2018 were analyzed retrospectively. We analyzed the prognostic significance of AB0 blood groups for PDAC(pancreatic ductal adenocarcinoma) patients based on stages of the disease (early, locally advanced, and metastatic).
RESULTS: We evaluated 366 patients diagnosed with pancreatic cancer.The median age of the patients was 65 (27-83). The median overall survival (OS) was 11 months (95% CI 9.49-12.50 months). Median survival was as follows: 13 months for blood group A (95% Cl, 10.59-15.41), 11 months for blood group B (95% Cl, 8.80-13.19),12 months for blood group AB (95% CI 6.63-17.36), and eight months for blood group 0 (95% Cl, 5.43-10.56) (p = 0.171). 304 (83.3%) of the patients were not alive at the end of the study. We concluded that the survival of those with 0 blood group was shorter in patients with metastatic pancreatic cancer (p <0.001), taking into account the relationship between stages and blood groups.
DISCUSSION AND CONCLUSION: There was no prognostic effect of AB0 blood groups on pancreatic cancer in our patient group. However, we found that blood group 0 negatively affected OS in metastatic pancreas cancer patients, based on the subgroup analysis according to stages.

Keywords: Pancreatic Cancer, AB0 Blood Group, Prognosis, Metastasis

Sema Turker, Ebru Cilbir, Deniz Can Güven, Hayriye Şahinli, Cengiz Karaçin, Şuayib Yalçın. The Prognostic Role of AB0 Blood Groups In Pancreas Cancer. Eastern J Med. 2021; 26(2): 224-227

Corresponding Author: Sema Turker, Türkiye
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