Evaluation of hematologic and biochemical parameters in patients with early stage uterine malignancy receiving radiotherapy

INTRODUCTION: Surgery is the primary choice of treatment fort this disorder. Radiotherapy is an important step of treatment in this cancer after surgery due to the stage of the disease. Lack of prospective randomised data for survival limits the use of adjuvant radiotherapy. Hovewer Adjuvant radiotherapy is suggested for high risk patients to reduce locoregional recurrence. The aim of this study is to define the statistical difference of hemogram, transaminases, kidney function tests and electrolyte changes in patients before starting radiotherapy, the end of radiotherapy, with the onset of acute side effects, and three months after finishing radiotherapy with the onset of chronic side effects.
METHODS: .18 patients with early stage endometrial malignancy attending to Adana Numune Training and Research Hospital have been included. This study has assessed the changes in hemogram, blood transaminases, ürea, creatinin and electrolyte values of patients before radiotherapy, at the last week of radiotherapy and three months after radiotherapy have been compared.
RESULTS: The values for were statistically significant for AST, Ca, LDH, urea, Hb ve HTC values before treatment, at the end of the treatment and three months after treatment (p<0.05).
DISCUSSION AND CONCLUSION: The effect of radiotheraphy seen as lower values of hemoglobin and hematocrite in endometrial malignancy patients resolved and become normal after three months of the radiotherapy.