ISSN 1301 - 0883 | E-ISSN: 1309-3886
Does Systemic Immune-Inflammation Index Predict Coronary Artery Disease Severity in Patients with ST-Elevated Myocardial Infarction Undergoing Percutaneous Coronary Intervention [Eastern J Med]
Eastern J Med. 2022; 27(4): 657-663 | DOI: 10.5505/ejm.2022.94824

Does Systemic Immune-Inflammation Index Predict Coronary Artery Disease Severity in Patients with ST-Elevated Myocardial Infarction Undergoing Percutaneous Coronary Intervention

dilay karabulut1, cennet yildiz1, fahrettin katkat2, Umut Karabulut3
1Department Of Cardiology, Bakirkoy Dr. Sadi Konuk Research And Educati̇on Hospital.
2. Department of Cardiology. Bağcılar Education and Research Hospital.
3Department of Cardiology. Acıbadem International Hospital, Istanbul

INTRODUCTION: Our aim was to assess value of systemic immune-inflammation index (SII) to predict coronary artery disease severity in patients with ST elevated myocardial infarction (STEMI) who underwent percutaneous coronary intervention (PCI).
METHODS: One hundred twenty six patients diagnosed as STEMI who underwent primary PCI were retrospectively analyzed. The severity of coronary stenosis was determined by the SYNTAX score (SxS). Patients with SxS<22 constituted group 0 and ≥22 constituted group 1. SII was obtained by multiplying number of platelets by neutrophil to lymphocyte ratio (SII = p × n/L ratio).
RESULTS: Lymphocyte count, ejection fraction and hematocrit was lower in patients with high SxS. Patients with higher SxS, had higher SIIs than those with lower SxS (1073.85 (147.28-6142.84) vs (778.88 (228.71-3179.78) p=0.044 respectively). SII had positive correlation with SxS, glucose, troponin T, creatinine, CK-MB levels and WBC count. SII was found to be predictor of high SxS (odds ratio: 1.001; 95% CI: 1.000-1.001; P = 0.018). SII with a cutoff value of 1124.7679 predicted the severity of coronary lesion with a sensitivity of 48% and specificity of 73.5% (AUC: 0.606, 95% CI: 0.507–0.705, p=0.46).
DISCUSSION AND CONCLUSION: Pre-procedural SII might provide an information about atherosclerotic burden in coronary artery in STEMI patients.

Keywords: Myocardial infarction, platelet activation, systemic immune-inflammation index

Corresponding Author: cennet yildiz, Türkiye
Manuscript Language: English
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