Does Systemic Immune-Inflammation Index Predict Coronary Artery Disease Severity in Patients with ST-Elevated Myocardial Infarction Undergoing Percutaneous Coronary Intervention

INTRODUCTION: Our aim was to assess value of systemic immune-inflammation index (SII) to predict coronary artery disease severity in patients with ST elevated myocardial infarction (STEMI) who underwent percutaneous coronary intervention (PCI).
METHODS: One hundred twenty six patients diagnosed as STEMI who underwent primary PCI were retrospectively analyzed. The severity of coronary stenosis was determined by the SYNTAX score (SxS). Patients with SxS<22 constituted group 0 and ≥22 constituted group 1. SII was obtained by multiplying number of platelets by neutrophil to lymphocyte ratio (SII = p × n/L ratio).
RESULTS: Lymphocyte count, ejection fraction and hematocrit was lower in patients with high SxS. Patients with higher SxS, had higher SIIs than those with lower SxS (1073.85 (147.28-6142.84) vs (778.88 (228.71-3179.78) p=0.044 respectively). SII had positive correlation with SxS, glucose, troponin T, creatinine, CK-MB levels and WBC count. SII was found to be predictor of high SxS (odds ratio: 1.001; 95% CI: 1.000-1.001; P = 0.018). SII with a cutoff value of 1124.7679 predicted the severity of coronary lesion with a sensitivity of 48% and specificity of 73.5% (AUC: 0.606, 95% CI: 0.507–0.705, p=0.46).
DISCUSSION AND CONCLUSION: Pre-procedural SII might provide an information about atherosclerotic burden in coronary artery in STEMI patients.