ISSN 1301 - 0883 | E-ISSN: 1309-3886
Serum Electrolyte Values and Blood Oxidative Stress Parameters in Patients with Focal and Generalized Epilepsy [Eastern J Med]
Eastern J Med. 2023; 28(1): 94-98 | DOI: 10.5505/ejm.2023.93195

Serum Electrolyte Values and Blood Oxidative Stress Parameters in Patients with Focal and Generalized Epilepsy

Gamze Sarı1, Aysu Kılıç2, Ferda Ilgen Uslu3, Şahabettin Selek4, Savas Ustunova2, Ismail Meral2
1Bezmialem Vakif University, Faculty of Medicine, Istanbul, Turkey
2Bezmialem Vakif University, Faculty of Medicine, Istanbul, Department of Physiology, Istanbul, Turkey
3Bezmialem Vakif University, Faculty of Medicine, Department of Neurology, Istanbul, Turkey
4Bezmialem Vakif University, Faculty of Medicine,Department of Biochemistry, Istanbul, Turkey

INTRODUCTION: Because epilepsy pathogenesis is affected by serum minerals and antioxidant enzymes, this study was designed to evaluate whether there was a relationship among electrolytes (Na, Ca, K, Cl, P, Mg), trace elements (Fe, Zn, Cu) and oxidative stress in patients with generalized or focal epilepsy.
METHODS: Twenty healthy individuals (control group), and 20 focal and 20 generalized epilepsy patients (patient groups) were included in the study. Control and patient groups were matched with age (30-40 years old), body mass index (25 -28) and sex (10 males and 10 females). Serum Na, Ca, K, Cl, P, Mg and Fe levels were analyzed in an autoanalyzer, serum Zn and Cu were analyzed in a mass spectrophotometer, total antioxidant status, total oxidant status and myeloperoxidase levels were measured spectrophotometrically.
RESULTS: The oxidative stress index increased (p<0.001) and the serum Na levels decreased (p<0.001) in focal epilepsy patients compared to the controls.
DISCUSSION AND CONCLUSION: It has been concluded these changes may make focal epilepsy patients more susceptible to seizures than generalized epilepsy patients.

Keywords: Focal epilepsy, generalized epilepsy, oxidative stress, trace elements, minerals

Corresponding Author: Ismail Meral, Türkiye
Manuscript Language: English
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