Eastern J Med. 2025; 30(1): 121-126 | DOI: 10.5505/ejm.2025.90836

Lymphocyte To HDL-C Ratio in Metabolic Dysfunction-Associated Steatotic Liver Disease

MINE OZTÜRK¹, Enver Avcý^2
1Department Of Endocrinology And Metabolism, Konya Numune Hospital, Konya, Turkey.
²Department Of Gastroenterology, Kto Karatay University Medicine Faculty Hospital, Konya, Turkey.

INTRODUCTION: We aimed to evaluate the lymphocyte / HDL cholesterol ratio as a new potential indicator in patients diagnosed with MASLD by ultrasonographic imaging. This ratio is easily calculated method.
METHODS: One hundred and seventy-three patients who came to our outpatient clinic between 1 February-15 November 2022 were included in the study. After measuring the height, weight and waist circumference of all patients, blood sample was drawn from the antecubital vein following a fasting period of at least 8 hours. The patients’ sex, age, and AST, ALT, albumin, glucose, insulin, HDL-C, lymphocyte values were recorded. Ultrasonographic imaging was used as the diagnostic method for hepatosteatosis in all cases. The fatty liver on ultrasonography was graded as grade 1-2-3.
RESULTS: Forty-eight (28.2%) patients had no fatty liver findings in ultrasonography. Patients with fatty liver findings were sorted as 52 patients (30.1%) with grade 1, 47 patients (27.2%) with grade 2, and 26 patients (15.0%) with grade 3 fatty liver. Among the cases with and without MASLD, the difference was significant between waist circumference(p=0.001), glucose(p=0.036) and body mass index(p=0.001) means. Among the cases with and without MASLD, the difference was not significant between age, AST, ALT, albumin, insulin, insulin resistance, HDL-C, lymphocytes, and lymphocytes / HDL-C ratio.


DISCUSSION AND CONCLUSION: Although there is no significant result, it is the first study to evaluate that lymphocyte/HDL-C ratio in MASLD, which is a common public health issue. More research is needed before stating that the lymphocyte/HDL-cholesterol ratio can be a new potential indicator of metabolic dysfunction-associated steatotic liver disease.

Keywords: Prognostic markers, Lymphocyte / HDL-C ratio, metabolic dysfunction-associated steatotic liver disease

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