The effect of antibiotherapy on high serum PSA levels

This study investigated the effect of antibiotics in patients with PSA value high than 4 ng/Ml on Tpsa, Fpsa and Fpsa/Tpsa ratio without missing cancer and avoiding unnecessary biopsies. A total of 96 patients were included into the study with detected high level than 4 ng/Ml serum PSA. Patients were divided into 2 groups according to the high level of PSA value. Group 1 included 49 patients with PSA level between 4-10 ng/Ml. Group 2 included 47 patients with PSA level higher than 10 ng/Ml. Patients were treated with Ciprofloxacin (500mg b.i.d.) orally for 2 weeks. All patients' PSA levels were evaluated and analyzed before and after antibiotic treatment. Statistical analyses were performed with SPSS version 18. A p value <0.05 was considered as significant. The mean age was 61.6 ±5.7 (51-75) years in group 1 and 63.1 ±8.7 (55-74) years in group 2. Suspicious DRE findings were significantly high in group 2. The mean Tpsa values were 6.82±0.42 and 5.93±0.36 before and after antibiotic treatment in group 1 respectively. There was no significant differences in Tpsa value before and after antibiotic treatment in group 1. The mean Tpsa values were 32.53±8.23 and 11.72±5.61 before and after antibiotic treatment in group 2 respectively. The mean Tpsa value decreased significantly after antibiotic treatment in group 2. Prostate cancer was detected in 32 patients after TRUS guided prostate biopsy. Prostate cancer was identified in 13 patients in group 1 and 19 patients in group 2. Antibiotic treatment in patients with PSA levels higher than 10 ng/Ml is effective on prostate biopsy decision and antibiotic treatment can prevent unnecessary prostate biopsies.