ISSN 1301 - 0883 | E-ISSN: 1309-3886
Unraveling Oxidative Stress in Moyamoya Disease: Exploring Thiol-Disulfide Dynamics and Ischemia-Modified Albumin [Eastern J Med]
Eastern J Med. 2024; 29(1): 39-46 | DOI: 10.5505/ejm.2024.87003

Unraveling Oxidative Stress in Moyamoya Disease: Exploring Thiol-Disulfide Dynamics and Ischemia-Modified Albumin

Göksal Günerhan1, Özgür Öcal1, Emin ÇAĞIL1, Zeynep Dağlar2, Ayberk Karaman1, Uğur Kemal GÜNDÜZ3, Harun Demirci4, Esra Fırat Oğuz5, Ozcan EREL6, Ahmet Deniz Belen1
1Health Science University, Ankara Bilkent City Hospital, Department of Neurosurgery, Ankara,Turkey
2Ministry of Health, Dörtyol State Hospital, Department of Neurosurgery, Hatay,Turkey
3Adıyaman University Education and Research Hospital,Department of Neurosurgery, Adıyaman,Turkey
4Ankara Yildirim Beyazit University Faculty of Medicine, Department of Neurosurgery, Ankara, Turkey
5University of Health Science, Ankara Bilkent City Hospital, Department of Biochemistry, Ankara, Turkey
6Yıldırım Beyazıt University,Faculty of Medicine,Department of Biochemistry, Ankara, Turkey

INTRODUCTION: This study aimed to explore the potential association between oxidative stress markers and Moyamoya Disease (MMD), a complex cerebrovascular disorder characterized by vascular constriction and collateral vessel formation. The study focused on thiol-disulfide homeostasis and ischemia-modified albumin (IMA) levels as indicators of oxidative stress.
METHODS: A total of 23 MMD patients and 23 control subjects were included in the study. Clinical assessments and comprehensive blood analyses were conducted to evaluate factors including age, gender, disease duration, treatment history, and biochemical parameters. Thiol-disulfide homeostasis parameters were measured using an automated method. Ischemia-modified albumin levels were also analyzed. Statistical analyses, including chi-square tests and ROC curve analysis, were performed to determine differences and potential diagnostic cut-off points.
RESULTS: Elevated levels of native thiol, total thiol, and disulfide were observed in the MMD patient group compared to the control group, statistical significant. Ischemia-modified albumin levels were notably higher in the patient group, corroborating the association between oxidative stress and ischemic events. ROC curve analysis identified potential diagnostic cut-off points for these markers. The study also highlighted clinical differences, including BMI, CRP levels, and the frequency of various symptoms, between the patient and control groups.
DISCUSSION AND CONCLUSION: Our study offers insights into the intricate interplay between oxidative stress and Moyamoya Disease. The statistically significant elevated levels of thiol-disulfide markers and ischemia-modified albumin suggest potential links to oxidative stress dynamics within MMD. These findings contribute to our understanding of oxidative stress in cerebrovascular diseases and open avenues for further research.

Keywords: Moyamoya Disease, Oxidative Stress, Thiol-Disulfide Homeostasis, Ischemia-Modified Albumin, Cerebrovascular Disorder

Göksal Günerhan, Özgür Öcal, Emin ÇAĞIL, Zeynep Dağlar, Ayberk Karaman, Uğur Kemal GÜNDÜZ, Harun Demirci, Esra Fırat Oğuz, Ozcan EREL, Ahmet Deniz Belen. Unraveling Oxidative Stress in Moyamoya Disease: Exploring Thiol-Disulfide Dynamics and Ischemia-Modified Albumin. Eastern J Med. 2024; 29(1): 39-46

Corresponding Author: Göksal Günerhan, Türkiye
Manuscript Language: English
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