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  Pulmonary langerhans cell histiocytosis: Two cases with varied radiologic findings [Eastern J Med]
Eastern J Med. 2016; 21(1): 45-49 | DOI: 10.5505/ejm.2016.83616  

Pulmonary langerhans cell histiocytosis: Two cases with varied radiologic findings

Hulya Gunbatar1, Alpaslan Yavuz2, Bunyamin Sertogullarindan1, Selami Ekin1, Selvi Asker1, Fuat Sayır3, Irfan Bayram4
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Pulmonary Langerhans Cell Histiocytosis (PLCH) is an idiopathic interstitial lung disease with Langerhans cell infiltration in the lung. PLCH X has non-spesific symptoms, and most patients have smoking history. A combination of stellate nodules, reticular and nodular opacities, upper zone cysts or honeycombing, preservation of lung volume and costophrenic angle sparing are highly specific for PLCH. To contribute to the literature, two cases are presented. First case is 30 years old man with 10 pack/years smoking history was admitted with cough and persevering interstitial opacities. Second case is 34 years old man with 15 pack/years smoking history was admitted with persistant cough. On thorax CT the first case had reticulonodular opacities at the perifery of the upper and middle zones, second case had multiple parenchymal cystic nodular lesions. Open lung biopsy performed, immunohistochemical examination CD1a, CD68, S100 detecting antigen-positive and histologically and radiologically confirmed diagnosed of PLCH.

Keywords: Pulmonary Langerhans cell histiocytosis, radiology, histology


Hulya Gunbatar, Alpaslan Yavuz, Bunyamin Sertogullarindan, Selami Ekin, Selvi Asker, Fuat Sayır, Irfan Bayram. Pulmonary langerhans cell histiocytosis: Two cases with varied radiologic findings. Eastern J Med. 2016; 21(1): 45-49


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