Effect of Postmenopausal Strontium Ranelate Treatment on Oxidative Stress in Rat Skin Tissue

INTRODUCTION: The effects of strontium ranelate in the treatment of post-menopausal osteoporosis on the free radical-antioxidant balance of the skin have not been fully elucidated. In this study, we investigated the effects of strontium ranelate treatment on oxidative stress parameters in the skin tissue of rats with the experimental osteoporosis model.
METHODS: Total 35 Wistar-Albino rats were divided to 5 groups as control group (Group I), oophorectomy group (Group II), strontium ranelate group (Group III), oophorectomy + strontium ranelate group (immediately after the overectomy) (Group IV) and overtectomy + strontium ranelat group (after three months of overectomy) (Group V). In Group III, IV and V, 500 mg/kg doses of strontium were given to rats by orally. At the end of the study, malondialdehyde (MDA) and glutathione (GSH) levels, superoxide dismutase (SOD) and catalase activities of the rats’ skin tissues were determined.
RESULTS: Catalase and SOD activities and GSH levels of all groups were found to be significantly lower than Group I (p<0.05). MDA levels of all groups were significantly higher than Group I (p<0.05). Catalase and SOD activities and GSH levels of Group IV and V were found to be significantly lower than Group II (p<0.05). MDA levels of Group IV and V were found to be significantly higher than Group II (p<0.05).
DISCUSSION AND CONCLUSION: In conclusion, strontium ranelate treatment in oophorectomized rats has resulted in an increase in oxidative stress in skin tissue and can cause to several skin disorders.