Eastern J Med. 2017; 22(2): 70-73 | DOI: 10.5505/ejm.2017.76486
Epstein-Barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: A distinct entity
Farah Dayana Zahedi1, Nik Mohd Hazleigh Nik Hussin2, Salina Husain1, Ramesh Kumar3, Balwant Singh Gendeh11Department Of Otorhinolaryngology-head And Neck Surgery Faculty Of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
2Department Of Otorhinolaryngology-head And Neck Surgery Faculty Of Medicine, Universiti Teknologi Malaysia, Selangor, Malaysia
3Neurosurgery Unit, Department Of Surgery Faculty Of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Introduction: Primary sinonasal nasopharyngeal-type undifferentiated carcinoma (PSNPC) is a rare variant of the sinonasal undifferentiated carcinoma (SNUC). The histological classification has implications on its management.
Case report: We report a case of a 32 year old lady who presented with progressive nasal obstruction due to a sinonasal tumour. Endoscopic excisionwas performed and histopathologicall examination confirmedPSNPC with positive Epstein Barr virus insitu hybridisation.
Conclusion: Identification and recognition of PSNPC as a separate clinicopathological entity from SNUC is important as it dictates the management of this rare variant. Immunohistochemical analysis is invaluable in this endeavor.
Keywords: paranasal sinus, sinonasal, undifferentiated carcinoma, Epstein-Barr virus, nasopharynx
Farah Dayana Zahedi, Nik Mohd Hazleigh Nik Hussin, Salina Husain, Ramesh Kumar, Balwant Singh Gendeh. Epstein-Barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: A distinct entity. Eastern J Med. 2017; 22(2): 70-73
Corresponding Author: Farah Dayana Zahedi, Malaysia
Manuscript Language: English