Patients Admitted To Our Center With Methanol Poisoning: Retrospective Analysis

INTRODUCTION: Methanol poisoning is caused by the production of toxic metabolites by the alcohol dehydrogenase enzyme;metabolic acidosis is a serious condition that can lead to life-threatening complications such as kidney failure, blindness, and death.In our study, it was aimed to examine the methanol poisoning cases admitted to the hospital terms of mortality and morbidity.
METHODS: Following the approval of the Ethics Committee(03/12/2019,Number: 1497),16 patients were retrospectively analyzed.The patients were divided into 2 groups as Group I(Survivor,n=11)and Group II(Nonsurvivor,n=5)and possible risk factors for mortality were examined.
RESULTS: No statistically significant difference was found in terms of mortality,age,gender,GCS at admission,HR,MAP,urea,creatinine, and GFR values(p>0.05).In patients with nonsurvivor;In terms of pH values;A statistically significant increase was found at the12thhr compared to the 1sthr(p=0.046).It was determined that the 1st hr PaCO2 were lower than Group I.(p=0.020).No significant difference was found in terms of HCO3 values at 1.,3.,6.,12.,24. and 48.hr according to mortality(p>0.05).In Group I;the increase in HCO3 values at the 12thhr compared to the 1st hr was found to be statistically significant(p=0.046).The methanol level was measured in 6 patients(5-249mg/dl).Ophthalmological findings were detected in 62%of the patients.The blood sugar of Group II was 132.8mg/dl(95-210)and the Group I was 216mg/dl(70-395).Hemodialysis was performed in 56.3%of the cases from the time of diagnosis.The total mortality rate is31.2%.
DISCUSSION AND CONCLUSION: On admission to the hospital due to methanol intoxication; here is no relationship between methanol blood level at admission and mortality but coma,GCS<7,seizures and metabolic acidosis(pH<6.9)are prognostic factors for fatal and permanent sequelae. Hemodialysis is considered the key element in the treatment of methanol intoxication.