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Correlation of Anti-MCV and Anti-CarP Antibodies with Other Clinical and Laboratory Parameters in Patients with Rheumatoid Arthritis
Khalid W Al-Maola1, Ali A. younis2, Firas M Al-Tae1, Ahmed A Al-Harbi11University of Mosul, College of Medicine, Department of Microbiology, Iraq2University Of Mosul, College of Medicine, Department of Microbiology, Iraq
INTRODUCTION: Anti-cyclic citrullinated peptides (anti-CCP) antibodies and rheumatoid factor (RF) represent the key biomarkers that harnessed to diagnose rheumatoid arthritis (RA). This work stands to appraise other less ascertain antibodies as Anti-Mutated Citrullinated Vimentin (Anti-MCV) or Anti-Carbamylated Protein (Anti-CarP) to be used for RA diagnosis.
METHODS: The current study was designed as a case-referent model including 60 RA patients and 30 controls. Sera levels of antibodies and RF were estimated via ELISA; and correlated with each other, and DAS28 score.
RESULTS: : Sera of 43.3% of patients own anti- MCV, while only 30% and 61.7% own anti-carp antibodies and RF respectively. Furthermore 66.7% tested positive for anti-CCP antibodies. Patients Anti-MCV was notably greater than among healthy controls (P value=0.0061). Statistically no significant difference between early, and established; or between seronegative, and seropositive patients. The sensitivity and specificity of anti-MCV for the diagnosis of RA were 43.3% and 96.7%. In regard to anti-CarP antibody, RA patients have significantly higher ODs than controls. Anti-CarP possessed a lower sensitivity (28.3%) and specificity (93.3%) in contrast to anti-MCV antibodies. The validity of anti-Carp antibodies to discriminate between early and established or between seronegative and seropositive RA seems to be low. Although both of anti- MCV and anti-CarP antibodies were correlated with each other, neither of them showed correlation with RF, anti-CCP or DAS 28 score.
DISCUSSION AND CONCLUSION: : Anti-MCV and anti-CarP antibodies are not superior to anti-ccp and RF as diagnostic indicators for RA, with limitation in discrimination between early, late, seronegative and seropositive RA.
Manuscript Language: English