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  The Protective Role Of Resveratrol On Serum Total Sialic Acid And Lipid-Bound Sialic Acid In Female Rats With Chronic Fluorosis [Eastern J Med]
Eastern J Med. 2016; 21(4): 168-172 | DOI: 10.5505/ejm.2016.69775  

The Protective Role Of Resveratrol On Serum Total Sialic Acid And Lipid-Bound Sialic Acid In Female Rats With Chronic Fluorosis

Gökhan Oto1, Suat Ekin2, Hulya Özdemir1, Mehmet Bulduk3, Hasan Uyar1, Ersoy Öksüz1
1Department of Medical Pharmacology,Yuzuncu Yil University, School of Medicine, Van, Turkey
2Department of Biochemistry,Yuzuncu Yil University, Faculty of Science, Van, Turkey
3Ercis Vocational School, Yuzuncu Yil University, Van, Turkey

INTRODUCTION: In the present study, the effect of resveratrol on serum total sialic acid (TSA) and lipid bound sialic acid (LSA) was investigated in the rats exposed to chronic fluoride.
METHODS: The study was administered using 32 female Sprague Dawley rats weighing 200-250 g. Rats were divided into four groups (n=8/group). Group I comprised the control group, group II was treated with sodium fluoride (NaF) (10 mg/lt/day), group III was treated resveratrol (50 mg/lt/day) and group IV was treated NaF+resveratrol for 90 days period. Total sialic acid (TSA) and lipid-bound sialic acid (LSA) were determined in serum samples.
RESULTS: Statistical analysis showed that the NaF group was significantly higher than the control group with regards to LSA (17.59±2.734 mg/dL, 12.61±2.013 mg/dL) and TSA (87.86± 8.34 mg/dL, 71.47± 8.57 mg/dL) levels (p<0.01 and p<0.05 respectively). Whereas the Resveratrol group was also significantly lower than the NaF group regarding LSA (13.21±2.848 mg/dL, 17.59±2.734 mg/dL) and TSA (72.44± 10.43 mg/dL, 87.86± 8.34 mg/dL) levels (p<0.05 and p<0.05 respectively), Moreover, no significant differences in LSA (14.62±1.85 mg/dL, 12.61±2.013 mg/dL) and TSA (81.19 ±10.24 mg/dL, 71.47± 8.57 mg/dL) levels were observed in the Resveratrol + NaF groups, as compared to the control group (p>0.05).
DISCUSSION AND CONCLUSION: The present study demonstrated slight positive and beneficial effect of resveratrol on the concentration levels of LSA and TSA in serum..

Keywords: TSA, LSA, fluorosis, resveratrol, rat


Gökhan Oto, Suat Ekin, Hulya Özdemir, Mehmet Bulduk, Hasan Uyar, Ersoy Öksüz. The Protective Role Of Resveratrol On Serum Total Sialic Acid And Lipid-Bound Sialic Acid In Female Rats With Chronic Fluorosis. Eastern J Med. 2016; 21(4): 168-172

Corresponding Author: Ersoy Öksüz, Türkiye


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