ISSN 1301 - 0883 / E-ISSN 1309 - 3886

  Gastric İntestinal Metaplasia and COVID 19 Infection [Eastern J Med]
Eastern J Med. 2020; 25(4): 571-575 | DOI: 10.5505/ejm.2020.68916  

Gastric İntestinal Metaplasia and COVID 19 Infection

Mesut Aydın1, Ahmet Cumhur DÜLGER2, serhat özer3, yaren dirik1, SIDDIK KESKİN4, Canan Demir5
1Department of Gastroenterology, Van Yuzuncu Yil University, Van, Turkey
2Department of Gastroenterology,Giresun University, Giresun, Turkey
3Department of Gastroenterology,Private Defne Hospital,Antakya,Turkey
4Department of Biostatistics, Van Yuzuncu Yil University,Van,Turkey
5Vocational School Of Healthcare, Van Yuzuncu Yil University, Van,Turkey

INTRODUCTION: Gastric intestinal metaplasia (GIM) is defined as immigration of enteric or colonic mucosa within gastric lining. COVID 19, which has been a global issue since late 2019, causes mostly respiratory symptoms; however, some patients may present with gastrointestinal symptoms including diarrhea, vomiting (5%) and abdominal pain ( 3.8%). A large Eestern study involving 78,985 patients revealed that prevalence of GIM in gastric biopsy specimens was 7%. We aimed found a clear association between acute COVID 19 infection and GIM in this work
METHODS: Between March and May 2020, we enrolled 39 patients with COVID 19 infection. An age-matched control group was selected from dyspeptic subjects without GIM. Gastroscopy with antral biopsy had been performed in all patients two years before pandemic began. All study subjects' histopathological records obtained by gastroscopic biopsy were evaluated and compared.
RESULTS: Data of 39 patients and 181 subjects were analyzed. Albumin and ferritin levels were found significantly lower and higher in patient group, respectively (p<0,05). MCV was higher in patient group (p<0,05). Intestinal metaplasia was found in 11 (28%) of 39 patients while in 7 (3,9%) of 181 controls (Table-2, p<0,05)
DISCUSSION AND CONCLUSION: GIM and COVID 19 infection could share same underlying etiologies and GIM may be a harbour for virus at gastrointestinal tractus. Focus on GIM prevention may block an enterance point of COVID 19 infection. The data above suggests that GIM affects gastric mucosal tissue with formation of toxic products, which may play a potential pathogenic role in developing COVID 19 infection

Keywords: COVID19, Intestinal metaplasia, Atrophy

Mesut Aydın, Ahmet Cumhur DÜLGER, serhat özer, yaren dirik, SIDDIK KESKİN, Canan Demir. Gastric İntestinal Metaplasia and COVID 19 Infection. Eastern J Med. 2020; 25(4): 571-575

Corresponding Author: Mesut Aydın, Türkiye

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