Effect of Bisphenol-A on Thyroid Hormones and Some Biochemical Parameters in Children with Juvenile Diabetes

INTRODUCTION: This study aims to investigate the effect of serum Bisphenol A (BPA) levels on thyroid hormones and some biochemical parameters in children with newly diagnosed Type 1 diabetes mellitus (T1DM).
METHODS: A total of 139 people, including 74 patients aged 0-18 years who were newly diagnosed with T1DM, 30 healthy siblings of these patients, and 35 healthy children, were included in the study. BPA, apelin, thyroid stimulating hormone (TSH), free T3 (T3), free T4 (T4), thyroglobulin antibody (anti-TG), thyroid peroxidase antibody (anti-TPO), total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride, C-peptide and glycosylated haemoglobin (HbA1c) levels were measured in the samples obtained from the volunteers.
RESULTS: Serum BPA concentrations were higher in children with T1DM compared to their siblings and healthy children (p<0.05). The apelin levels in the patient group were observed to be lower than those in their siblings and the healthy children (p<0.05). In all three groups, a negative correlation was identified between BPA and apelin. There was no correlation between BPA and TSH, T3 and T4 levels in all three groups (p>0.05). Similarly, no correlation was detected between BPA and total cholesterol, LDL, HDL, triglyceride, C-peptide, HbA1c, anti-TG and anti-TPO (p>0.05).
DISCUSSION AND CONCLUSION: In summary, this study shows that BPA levels were increased and apelin levels were decreased in children with T1DM, with a negative relationship between the two. Taken together, our results suggest that BPA may have a role in the pathogenesis or progression of T1DM. Low apelin may be associated with the progression of T1DM.