ISSN 1301 - 0883 | E-ISSN: 2687-5101
The Comparative Effects of Pentoxifylline and Ursodeoxycholic Acid on IL-1ß, IL-6, IL-8 AND TNF-? Levels in Nonalcoholic Fatty Liver [Eastern J Med]
Eastern J Med. 2003; 8(2): 27-32

The Comparative Effects of Pentoxifylline and Ursodeoxycholic Acid on IL-1ß, IL-6, IL-8 AND TNF-? Levels in Nonalcoholic Fatty Liver

İlyas Tuncer1, İsmail Uygan2, Haluk Dülger3, Kürşat Türkdoğan4, Ramazan Şekeroğlu3
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To investigate the comparative effects of the pentoxifylline (PTX) and ursodeoxycholic acid (UDCA) on IL-1ß, IL-6, IL-8 and TNF-? in non-alcoholic fatty liver (NAFL) cases. Method: Twenty-eight cases diagnosed to have NAFL were included in our study. The cases were divided into 3 groups. 20 mg/kg/day PTX was given to the subjects in group A (6 male, 4 female), 15 mg/kg/ day UDCA was given to the subjects in group B (5 males, 5 females) for 6 months. The cases in group C (5 male, 3 female) were followed as control group. The biochemical values and cytokine levels of the cases were evaluated before and at the end of the sixth month of the treatment. Results: When compared with the serum cytokine levels before and after the treatment, IL-8 and TNF-? levels were found to be significantly decreased both in group A and group B (p< 0.05), whereas there was no statistically significant change in IL-1ß and IL-6 levels (p > 0.05). Conclusion: While PTX and UDCA significantly decreased the serum IL-8 and TNF-? levels in NAFL, their effects on IL-1ß and IL-6 were not significant.

Keywords: Non-alcoholic fatty liver, pentoxifylline, ursodeoxycholic acid, cytokines

İlyas Tuncer, İsmail Uygan, Haluk Dülger, Kürşat Türkdoğan, Ramazan Şekeroğlu. The Comparative Effects of Pentoxifylline and Ursodeoxycholic Acid on IL-1ß, IL-6, IL-8 AND TNF-? Levels in Nonalcoholic Fatty Liver. Eastern J Med. 2003; 8(2): 27-32
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