ISSN 1301 - 0883 / E-ISSN 1309 - 3886
 
 








  Histopathological and mechanical properties of different meshes in a rat model of pelvic prolapse surgery [Eastern J Med]
Eastern J Med. 2017; 22(2): 45-52 | DOI: 10.5505/ejm.2017.26349  

Histopathological and mechanical properties of different meshes in a rat model of pelvic prolapse surgery

Gulhan Gunes Elci1, Erkan Elci1, Cihan Kaya2, Numan Cim3, Ali Kolusari3, Remzi Erten4, Gulay Bulut4
1Ministry of Health of the Republic of Turkey Van Region Training and Research Hospital, Department of Obstetrics and Gynecology, Van, Turkey
2Bakirköy Dr Sadi Konuk Training and Research Hospital, Department of Obstetrics and Gynecology, Istanbul, Turkey
3Yüzüncü Yil University, Faculty of Medicine, Department of Obstetrics and Gynecology, Van, Turkey
4Yüzüncü Yil University Faculty of Medicine Department of Pathology, Van, Turkey

INTRODUCTION: Different types of mesh materials are used to support pelvic structures in urogynecologic procedures. Our aim was to compare histopathological and mechanical effects of Prolene®, UltraPro®, Vypro II®, and Permacol® meshes used in pelvic organ prolapse.
METHODS: Thirty Sprague-Dawley rats were randomized into five groups. Group 1 served as a sham-operated control (n=6); Prolene® was used in group 2 (n=6), UltraPro® in group 3 (n=6), Vypro II® in group 4 (n=6), and Permacol® in group 5 (n=6). A 0.5 × 1 cm mesh was placed between the paravaginal tissue and bladder. After 12 weeks, the rats were reoperated and meshes were excised. Histopathological tissue reactions were compared.
RESULTS: The muscle penetration rate was 67% in the Prolene® group, which was significantly higher than that in the other groups (p=0.026). Minimum preserved postoperative surface area was seen with Prolene® at 0.31 cm2 and maximum with UltraPro® at 0.45 cm2, which was statistically significant. UltraPro® had the most preserved postoperative surface area and less shrinkage than the other meshes.
DISCUSSION AND CONCLUSION: The mesh materials cause an inflammatory reaction in surrounding tissue. Prolene® mesh had superior muscle penetration and tensile strength compared to the other materials.

Keywords: pelvic organ prolapse, polypropylene, surgical mesh, tensile strength


Gulhan Gunes Elci, Erkan Elci, Cihan Kaya, Numan Cim, Ali Kolusari, Remzi Erten, Gulay Bulut. Histopathological and mechanical properties of different meshes in a rat model of pelvic prolapse surgery. Eastern J Med. 2017; 22(2): 45-52

Corresponding Author: Gulhan Gunes Elci, Türkiye


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