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  Genetics of Premature Ovarian Failure [Eastern J Med]
Eastern J Med. 2018; 23(2): 135-140 | DOI: 10.5505/ejm.2018.14622  

Genetics of Premature Ovarian Failure

Harun Egemen Tolunay1, Barış Boza1, Bulut Varlı2
1Van Yuzuncu Yıl University Obstetrics And Gynecology
2Van Ercis State Hospital

Premature ovarian failure was defined as the cut-off of menstrual period for at least 4-6 months before 40 years of age, and FSH values measured over a month were over 40 IU / L. Although etiology is not fully understood, it is thought that genetic, immunological and environmental factors can play a role. Nowadays, translational and deletion in the critical regions (Xq13-26) on the X chromosome are defined in the developmental light in the genetic area. New approaches have been developed in clinical follow-up and treatment in recent years. It has been reported that caution should be taken in the follow-up, especially in terms of osteoporosis. In this article, recent literature on premature ovarian failure attempted to reveal current genetic etiology of premature ovarian failure.

Keywords: Premature ovarian failure, genetic reasons, ovarian aging


Harun Egemen Tolunay, Barış Boza, Bulut Varlı. Genetics of Premature Ovarian Failure. Eastern J Med. 2018; 23(2): 135-140

Corresponding Author: Harun Egemen Tolunay, Türkiye


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