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Fetal Pulmonary Artery Doppler Evaluation in Pregnant Women with Behçet’s Disease: A Case-Control Study
Muradiye Yildirim1, Deniz Oluklu1, Dilek Menekşe Beşer1, Derya Uyan Hendem1, Duygu Tugrul Ersak1, Özgür Kara2, Atakan Tanacan2, Dilek Şahin21Department of Obstetrics and Gynecology, Division of Perinatology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey2University of Health Sciences, Department of Obstetrics and Gynecology, Division of Perinatology, Turkish Ministry of Health Ankara City Hospital, Ankara, Turkey
INTRODUCTION: To investigate the effect of maternal Behçet disease (BD) on fetal pulmonary artery parameters with spectral Doppler
METHODS: This case-control study consisted of 21 pregnant women diagnosed with BD between 29-30 weeks of gestation. The control group enrolled 42 low-risk healthy pregnant women, two for each case, whose gestational weeks matched the case group. Demographic and obstetric characteristics of the participants and the presence of attacks during pregnancy were recorded. Pulmonary artery acceleration time (AT), ejection time (ET), and AT/ ET ratio (PATET) parameters determined by spectral Doppler were calculated.
RESULTS: Maternal demographic and obstetric characteristics were similar between groups. Fetal pulmonary artery AT, ET, and AT/ET ratios were compared between the cases and controls. The AT was significantly shorter, and the AT/ET ratio was significantly lower in the cases (p<0.001, p<0.001). ET values were similar in both groups (p=0.567). There was no difference in gestational age and Doppler values between those who had an attack during pregnancy and those who did not.
DISCUSSION AND CONCLUSION: Maternal BD, a chronic inflammatory vasculitis, causes fetal pulmonary artery circulation changes determined by spectral Doppler. Pulmonary artery AT, ET, and PATET values, which are important for respiratory complications, may be valuable in this patient group's obstetric management.
Manuscript Language: English