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Importance of Prostate-Specific Membrane Antigen in Paget's Disease of the Breast
İsmail Zihni1, Mehmet Zafer Sabuncuoğlu3, İsa Sözen3, Girayhan Çelik3, Kemal Kürşat Bozkurt2, Seda Arzuman Baştürk1, Ahmet Dal31Department of Surgical Oncology, Süleyman Demirel University, Isparta, Turkey2Department of Pathology, Süleyman Demirel University, Isparta, Turkey
3Department of General Surgery, Süleyman Demirel University, Isparta, Turkey
INTRODUCTION: In this study, the relationship of prostate specific membrane antigen (PSMA), a type-2 transmembrane glycoprotein, with the Her-2 Receptor and prognosis of the disease in cases with Paget's Disease of the Breast was investigated.
METHODS: The data of 14 patients diagnosed and treated with Paget's disease of the breast between July 2013 and March 2020 in the General Surgery Clinic were evaluated retrospectively.
RESULTS: After the pathological diagnosis was made, all patients underwent modified radical mastectomy. Paget's disease was found together with invasive ductal carcinoma in one patient, and Paget's disease was found together with ductal carcinoma in situ in 7 patients (50%). Staining in malignant tissue with PSMA was detected in only two patients. The normal dermis venules of other patients were stained with PSMA. In the subsequent follow-ups, lung and bone metastases were detected. The other patient stained with PSMA showed weak PSMA expression in malignant epidermal cells in the epidermis (The patient's tumor invasion grade was T2, there was no axillary lymph node metastasis, ki-67 expression was 10%, estrogen, progesterone and HER2 receptor were positive.
DISCUSSION AND CONCLUSION: Although studies showing the relationship between PSMA and breast malignancies are limited and there is no literature information; In our study, two patients with staining with PSMA had high grade and distant metastases with ki-67. Larger studies are needed to establish a link between PSMA and Paget's disease of the breast.
Manuscript Language: English