INTRODUCTION: Preeclampsia is a hypertensive disorder of pregnancy that usually starts after the 20th week of pregnancy and affects 2-8% of pregnant women worldwide.In preeclampsia,glomerular endothelial damage,formation of podocituria and tubular hyperfiltration mechanisms play a role in the pathogenesis of proteinuria.
KIRREL(NEPH1) is a protein from the nephrin adhesion family.Prevents podocyte damage. In this way, it maintains glomerular filtration and glomerular function.
The aim of the study is to show whether the levels of KIRREL(NEPH1),an adhesion molecule protein,decrease in pregnant women with preeclampsia and to use it in the prediction of preeclampsia patients,to intervene in these patients beforehand.
METHODS: A total of 80 pregnant women,40 with preeclampsia and 40 with normotensive, who applied to the Gynecology and Obstetrics Clinic of Kanuni Sultan Süleyman Training and Research Hospital were included in our study.Our patients were diagnosed with preeclampsia according to the ACOG diagnostic criteria.
RESULTS: While the mean KIRREL level in the maternal blood of the pregnant women included in the study was 3.38 (mg/dl)in the study group,it was 6.46 (mg/dl)in the control group, and there was a significant difference between the groups. In the study group, the KIRREL level in maternal blood was lower than in normal pregnant women (p = 0.377).
DISCUSSION AND CONCLUSION: In our study, serum KIRREL levels were found to be significantly lower in the study group compared to the control group.However, KIRREL levels have been evaluated as an inadequate test in the prediction of preeclampsia.This may be related to the fact that there are many factors affecting the development of preeclampsia.