Effects of Epigallocatechin Gallate Administration on Diabetic Rat Myocardial Tissue

INTRODUCTION: This work aimed to research the actions of Epigallocatechin Gallate (EGCG) on heart tissue in diabetic rats.
METHODS: In the work, twenty-eight rats were taken and splited into 4 groups as control group, EGCG, Diabetes, and Diabetes + EGCG. A one dose of 45 mg/kg streptozotocin (STZ) was performed intraperitoneally to the groups to be described with diabetes. EGCG was given to the animals at 20 mg/kg/day for 14 days using an intragastric tube. The heart tissue was colored with Masson trichrome and Hematoxylin-Eosin (H&E). Heart tissue was evaluated by histopathological and immunohistochemical (Collagen type III) methods.
RESULTS: In the histological structure of the diabetic group, irregular heart muscle fibers, inflammatory cell infiltration, and necrotic myocytes in the myocardium and increased collagen type 3 expression were observed, and these findings were found to decrease in the Diabetes + EGCG group. It was found that the density of collagen content increased in the Diabetes group. This finding decreased in the Diabetes + EGCG group.
DISCUSSION AND CONCLUSION: The findings of our study suggest that EGCG may have ameliorative effects on induced cardiotoxicity in diabetic rats.