ISSN 1301 - 0883 / E-ISSN 1309 - 3886
 
 








  Morphologic Effect of Intermittent Fasting on Sciatic Nerve in Acrylamide Administered Rats [Eastern J Med]
Eastern J Med. 2018; 23(3): 187-190 | DOI: 10.5505/ejm.2018.06078  

Morphologic Effect of Intermittent Fasting on Sciatic Nerve in Acrylamide Administered Rats

Elif Kaval Oğuz
Department of Science Education, Van Yüzüncü Yıl University, 65080, Van/TURKEY

INTRODUCTION: Acrylamide is a widely used chemical in industrial manufacturing and laboratory studies. Long term use of this chemical causes axonal degeneration.
METHODS: In this study, 20 mg/kg of acrylamide was administered to Wistar-albino rats daily and effects on sciatic nerve and any potential protective activity of intermittent fasting were investigated. Effect of acrylamide and intermittent fasting was assessed by immunefluorescent method.
RESULTS: As a result paralysis in hind legs and coordination problems during walking was observed in acrylamide administered group. These problems were less frequent in intermittent fasting group. In addition, a decrease in neurofilament number was observed in acrylamide group whereas neurofilament level was similar with control group in intermittent fasting group.
DISCUSSION AND CONCLUSION: Concomitant administration of acrylamide and intermittent fasting caused ameliorating effect of intermittent fasting. A potential protective effect of intermittent fasting against acrylamide can be considered according to such results.

Keywords: Acrylamide, Neuropathy, Axon, intermittent fasting


Elif Kaval Oğuz. Morphologic Effect of Intermittent Fasting on Sciatic Nerve in Acrylamide Administered Rats. Eastern J Med. 2018; 23(3): 187-190

Corresponding Author: Elif Kaval Oğuz, Türkiye


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