ISSN 1301 - 0883 / E-ISSN 1309 - 3886

  Mortality and severity related factors during the admission: H1N1 pneumonia [Eastern J Med]
Eastern J Med. 2018; 23(3): 168-176 | DOI: 10.5505/ejm.2018.04834  

Mortality and severity related factors during the admission: H1N1 pneumonia

Hanifi Yıldız1, Selami Ekin1, Ahmet Arısoy1, Hüseyin Akdeniz2, Hasan Ali Gümrükçüoğlu3, Selvi Aşker1, Aysel Sünnetçioğlu1, Hülya Günbatar1, Nureddin Yüzkat4, Mehmet Hakan Bilgin5, Mesut Özgökçe2, Mahfuz Turan6
1Yuzuncu Yil University Faculty of Medicine, Department of Chest Disease, Van, Turkey
2Yuzuncu Yil University Faculty of Medicine, Department of Radiology, Van, Turkey
3Private Lokman Hekim Hospital, Departmen of Cardiology, Van, Turkey
4Yuzuncu Yil University Faculty of Medicine, Department of Anesthesiology, Van, Turkey
5Private Lokman Hekim Hospital, Departmen of Chest disease, Van, Turkey
6Yuzuncu Yil University Faculty of Medicine, Department of Otorhinolaryngology, Van, Turkey

INTRODUCTION: In our country, fatal cases of H1N1 pneumonia were detected between 2015-2016 years. Our aim is to analyze the mortality and severity related factors, during admission of these patients.
METHODS: By conducting a retrospective analysis, 17 cases, confirmed to have H1N1 pneumonia, included in the study. Findings were compared in terms of ARDS and mortality.
RESULTS: ICU and hospital mortality rates were 50% and 30%. The mean age of patients was 50 years. Serum LDH, CK, CK-MB, CRP AST, ALT levels, and the neutrophil-to-lymphocyte ratio (NLR) were found to be increased. In terms of co-infections, there wasn't a significant difference between died and survived patients. The mortality rate was 50% in patients with ARDS. Tere was no relationship between hospital stay with mortality. The symptom of restlessness was related to mortality, and presence of ARDS (P<.05). In died and alive patients, the mean-ranks of PaO2, SpO2, and CURB-65 scores were 3.5, 9.7, 4.3, 10.96, 14.6, and 6.6, respectively (P<.05). PaO2 and SpO2 values were lower, and CURB-65 scores were higher in dead patients. SpO2 <79.5, PaO2 <62.5, and CURB-65 scores ≥2 were related to mortality (P<.05). However, CURB-65 <2 didn’t exclude severe pneumonia. There wasn't a relationship between comorbid diseases and mortality. The main radiographic finding was bilateral infiltrates.
DISCUSSION AND CONCLUSION: This study suggests that PaO2, SpO2, and CURB scores of ≥2 and the presence of restlessness can be used to predict the severity and mortality in patients suspected to have H1N1 pneumonia, during admission.

Keywords: Influenza A Virus H1N1 Subtype, Pneumonia Viral, Severe Acute Respiratory Syndrome, Signs and Symptoms

Hanifi Yıldız, Selami Ekin, Ahmet Arısoy, Hüseyin Akdeniz, Hasan Ali Gümrükçüoğlu, Selvi Aşker, Aysel Sünnetçioğlu, Hülya Günbatar, Nureddin Yüzkat, Mehmet Hakan Bilgin, Mesut Özgökçe, Mahfuz Turan. Mortality and severity related factors during the admission: H1N1 pneumonia. Eastern J Med. 2018; 23(3): 168-176

Corresponding Author: Hanifi Yıldız, Türkiye

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