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The relationship between histomorphological patterns and clinicopathological features in high-grade serous ovarian carcinoma
Evren Uzun1, Hatice Kübra Şile1, İbrahim Taşkum2, Fatma Sucu3, Erkan Şimşek41Department of Pathology, Gaziantep University, Gaziantep, Turkey2Department of Obstetrics and Gynecology, Gaziantep City Hospital, Gaziantep, Turkey
3Department of Family Medicine, Cengiz Gokcek Obstetrics and Pediatrics Hospital, Gaziantep, Turkey
4Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Gaziantep City Hospital, Gaziantep
INTRODUCTION: High-grade serous ovarian carcinoma (HGSC) is heterogeneous tumours in terms of morphology, genetics, and clinical presentation. The SET pattern (solid, pseudoendometrioid, and transitional-like) is associated with BRCA mutations and reflect distinct biological behaviour. The present study was conducted with the objective of evaluating the relationship between SET and non-SET patterns, and their clinicopathological and genetic characteristics.
METHODS: The present study comprised 83 patients diagnosed with HGSC between the years 2010-2020. Patients with any SET pattern (SET-predominant or focal-SET) were compared with non-SET cases, and SET-predominant cases with non-SET cases after excluding focal-SET. A comprehensive comparison was conducted between the groups with respect to age, FIGO-stage, regional lymph node involvement, regional and distant metastasis, ascites cytology, CA-125 level, and BRCA mutation status.
RESULTS: The SET-predominant pattern was detected in 41.0% of cases while focal SET cases were 15.7%. Advanced FIGO stage (III–IV) was more prevalent in the non-SET group. Regional lymph node involvement was significantly high in the non-SET group compared to the SET-predominant group (41.7%vs.14.7%;p=0.017). Regional and distant metastasis rates were higher in the non-SET group. Median CA-125 levels tended to be lower in the SET-predominant group. The prevalence of the BRCA mutation was found to be significantly higher in the SET-predominant and SET-focal/predominant groups compared to the non-SET group (61.8% and 51.1%vs.2.8%, respectively;p<0.001).
DISCUSSION AND CONCLUSION: The SET pattern in HGSC is strongly associated with the presence of a BRCA mutation. The findings of this study indicate that the reporting of the SET pattern in routine pathological evaluation is clinically and biologically significant.
Keywords: ovary, serous, carcinoma, BRCA, mutation, SET, pattern
Manuscript Language: English