Evaluation of the relationship between uric acid level and urýc acide/albumin ratio with stent thrombosis in patients presenting acute coronary syndrome

INTRODUCTION: This study aimed to evaluate the relationship between uric acid level and urýc acide/albumin ratio (UAR) and stent thrombosis in patients with acute coronary syndrome (ACS).
METHODS: This study was conducted using a single-center retrospective cohort design. The study included 67 patients who underwent interventional treatment for acute coronary syndrome, followed by re-interventional treatment for stent thrombosis within one year, as well as 75 patients who were managed with medical therapy for one year and did not require re-intervention.


RESULTS: Stent thrombosis is significantly associated with diabetes and hyperlipidemia.(respectively p=0,001, p=0,002) Uric acid levels were significantly higher and UAR was significantly lower in the stent thrombosis group. (respectively p= 0,001, p=0,001) The development of no reflow and post-dilatation was more frequent in the stent thrombosis group. ROC analysis revealed that a uric acid cut-off value of 5.55 had a sensitivity of 59.7% and a specificity of 64% for predicting stent thrombosis.
DISCUSSION AND CONCLUSION: The relationship between uric acid levels, UAR, and stent thrombosis likely involves complex processes including inflammation and oxidative stress. Understanding these relationships may contribute to the development of targeted interventions to reduce the risk of stent thrombosis and improve the outcomes of ACS patients undergoing stent implantation.