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Diagnostic Value of Plasma Atherogenicity Index for Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus
Gülsen Şener1, Esra Deniz Kahvecioğlu21Department of Biochemistry, Başakşehir Çam and Sakura City Hospital,Istanbul, Turkey2Department of Internal Medicine, Başakşehir Çam and Sakura City Hospital,Istanbul, Turkey
INTRODUCTION: Biochemical markers play a crucial role in the early diagnosis of diabetic nephropathy (DN), a common complication of type 2 diabetes mellitus (T2DM). This study aims to assess the plasma atherogenic index (AIP) in patients with T2DM who have DN, and evaluate the relationship between this parameter and other metabolic parameters, to determine its effectiveness in predicting the development and severity of DN.
METHODS: This retrospective study included 1,902 adult patients diagnosed with T2DM and 455 healthy controls. The T2DM group was further classified based on the albumin/creatinine ratio (UACR) into 770 patients without microalbuminuria, 701 patients with microalbuminuria, and 431 patients with macroalbuminuria.
RESULTS: In the T2DM group, levels of creatinine, uric acid, HbA1c, cholesterol, triglycerides, UACR, and AIP increased in the microalbuminuria group compared to the normoalbuminuria group, with the highest levels observed in the macroalbuminuria group (p =0.000 for each). AIP showed a significant positive correlation with HbA1c and triglycerides. Binary logistic regression analysis indicated that AIP and triglyceride levels had a significant impact on the likelihood of having T2DM with microalbuminuria.
DISCUSSION AND CONCLUSION: According to our findings, AIP is associated with the presence and severity of DN in patients with T2DM and serves as an independent risk factor for DN. Therefore, we believe that AIP is a reliable biomarker that can be used additionally to assess risk, determine severity, monitor progression, and guide DN treatment in patients with T2DM.
Manuscript Language: English