Eastern J Med. 2010; 15(2): 57-62

Etiologic agents and extended-spectrum beta-lactamase production in urinary tract infections in Sanandaj, Iran

Rashid Ramazan zadeh¹

Extended-spectrum ß-lactamases has emerged as an important mechanism of resistance in Gram-negative bacteria. In this study, we aimed to determine the frequency of extended spectrum beta lactamase producing isolates in (urinary tract infections). ESBL-production was tested by the double-disc synergy method and more confirmed by PCR amplification. Out of 188 isolated microorganisms Escherichia coli (80%) was the most frequent. Production was determined in 14.5% of clinically gram negative isolates. CTX-M type was the most prevalent type (12.7%) and SHV and TEM type were in the next ranks. Our data indicate the spread of these enzymes in clinically gram negative isolates in urinary tract samples collected from two general hospitals of Sanandaj.

Keywords: Urinary tract infections; extended-spectrum ßeta-lactamase; Escherichia coli

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