Eastern J Med. 2025; 30(1): 159-166 | DOI: 10.5505/ejm.2025.98965

The Relationship Between Inflammatory Parameters and the Duration of Febrile Neutropenia in Children with Febrile Neutropenia

Hatice Uygun¹, Esra Pekpak Sahinoglu², Ayse Ceyda Oren², Mohamad Alzalek³, Tanyeli Güneyligil Kazaz⁴, Sinan Akbayram^2
1Department of Pediatric Infectious Disease, Gaziantep University School of Medicine, Gaziantep, Türkiye.
²Department Of Pediatric Hematology And Oncology, Gaziantep Liv Hospital, Gaziantep, Türkiye.
³Department Of Pediatrics, Gaziantep University School Of Medicine, Gaziantep, Türkiye.
⁴Department Of Biostatistics, Gaziantep University School Of Medicine, Gaziantep, Türkiye.

INTRODUCTION: Febrile neutropenia is the most common complication and emergency condition frequently seen in pediatric patients receiving cytotoxic chemotherapy. Indices calculated using various ratios of parameters in complete blood counts are important predictors of various outcomes in conditions where the inflammatory process is at the forefront. This study aimed to investigate whether Neutrophil-Lymphocyte, Platelet-Lymphocyte, Monocyte-Lymphocyte ratio,and Systemic Immuno-Inflammation Index, Systemic Inflammation Response Index are effective markers on the duration of febrile neutropenia in children diagnosed with febrile neutropenia.


METHODS: This retrospective analysis involved 59 pediatric patients diagnosed with cancer-related febrile neutropenia. Among the participants, 52.5% (n=31) were classified in the short-duration febrile neutropenia category, comprising 51.6% (n=16) males and 48.4% (n=15) females. Conversely, 47.5% (n=28) were categorized in the long-duration febrile neutropenia group, which included 57.1% (n=16) males and 42.9% (n=12) females.


RESULTS: In the statistical analysis of the indices obtained from the ratios of complete blood count parameters measured on the first day of febrile neutropenia, there was a significant difference between the groups in terms of the Platelet/Lymphocyte ratio (p=0.045).
DISCUSSION AND CONCLUSION: This study suggested that various inflammatory parameters do not have a significant predictive effect on the duration of febrile neutropenia in pediatric patients monitored for short-term and long-term neutropenic fever. In our research, the group with prolonged neutropenia exhibited a decrease in Platelet/Lymphocyte ratio, which contrasts with existing literature. This discrepancy may be attributed to the fact that a substantial portion of the pediatric patients diagnosed with febrile neutropenia had a primary diagnosis of leukemia.

Keywords: Child, Febrile Neutropenia, Monocyte-Lymphocyte Ratio, Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, Systemic Immune Inflammation Index, Systemic Inflammation Response Index.

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