XQuick Search
Investigation of Irisin Level in Brucella Patients
Sermin Algül1, Feray Ferda Senol2, Seda Uğraş3, Fatih Esmer4, Mehmet Kara1, Pinar Tanritanir Ekici5, Oğuz Özçelik61Van Yuzuncu Yil University, Faculty Of Medicine, Department Of Physiology, Van, Turkey2Elazig Fethi Sekin City Hospital, Department Of Microbiology And Clinical Microbiology, Elazig, Turkey
3Bozok University, Faculty Of Medicine, Department Of Physiology, Yozgat, Turkey
4Sanlıurfa Mehmet Akif İnan Education And Research Hospital, Department Of Infectious Diseases And Clinical Microbiology, Sanlıurfa, Turkey
5Van Yuzuncu Yil University, Faculty of Health Sciences, Department of Midwifery, Van, Turkey
6Kastamonu University, Faculty of Medicine, Department of Physiology, Kastamonu, Turkey
INTRODUCTION: Objective: This study aimed to determine whether the changes in the metabolism of Brucella patients affect the irisin hormone. Also, it is aimed to investigate the relationships between other laboratory findings used in the diagnosis of brucellosis patients and the irisin hormone.
METHODS: Material and Method: 160 persons (80 brucellosis, 80 controls) were included in this study. Blood was drawn from the people participating in the study following their overnight fast. Irisin level was measured by ELISA method, CRP and sedimentation levels were measured using autoanalysers and commercial kits.
RESULTS: Results: It was determined that the irisin level of Brucella patients was statistically significantly higher than the control group (p <0.05). It was determined that there is a negative correlation between irisin level and CRP and sedimentation level in Brucella patients.
DISCUSSION AND CONCLUSION: Conclusion: In Brucella patients, the higher irisin level than the control group showed a negative correlation with CRP and sedimentation levels, which are an infection diagnosis criteria; It suggests that the level of irisin can be considered as a supportive diagnostic marker in these patients. Further studies are needed to evaluate irisin hormone as a supportive diagnostic criterion.
Manuscript Language: English