ISSN 1301 - 0883 | E-ISSN: 1309-3886
Assessment of patients with thrombotic thrombocytopenic purpura [Eastern J Med]
Eastern J Med. 2010; 15(1): 15-20

Assessment of patients with thrombotic thrombocytopenic purpura

Cengiz Demir1, Abdullah Altıntaş2, Semir Paşa3, M. Ali Kaplan4, Yüksel Küçükzeybek2, Orhan Ayyıldız4
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Thrombotic thrombocytopenic purpura (TTP) is a severe microvascular occlusive thrombotic microangiopathy characterized by systemic platelet aggregation, organ ischemia, profound thrombocytopenia, and fragmentation of erythrocytes. Unexplained occurrence of thrombocytopenia and anemia should prompt immediate consideration of the diagnosis and evaluation of peripheral blood smear for evidence microangiopathic hemolytic anemia. Excellent remission and survival rates were achieved by therapeutic plasma exchange. We reviewed characteristics and response rates to plasmapheresis of our TTP patients. A total of 25 cases were diagnosed. The parameters of hemoglobin and platelet were analyzed at presentation, as well as the number of plasmapheresis sessions and adjunctive treatment given. We found a response rate of 80 percent to plasma exchange. Response was better in 23 patients who presented with idiopathic TTP. Response was poor in patients with TTP secondary to underlying metastatic carcinoma. Two patients relapsed and one of the relapsed patients died. Plasmapheresis is mandatory and effective for primary TTP. Plasmapheresis may not be effective in all instances, especially if TTP is secondary to underlying disseminated cancer.

Keywords: Thrombotic thrombocytopenic purpura, therapeutic plasmapheresis


Manuscript Language: English
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Demir, C., Altıntaş, A., Paşa, S., Kaplan, M. A., Küçükzeybek, Y., & Ayyıldız, O. (2010). Assessment of patients with thrombotic thrombocytopenic purpura. Eastern J Med, 15(1), 15-20. https://doi.org/.
Demir C, Altıntaş A, Paşa S, Kaplan MA, Küçükzeybek Y, Ayyıldız O. Assessment of patients with thrombotic thrombocytopenic purpura. Eastern J Med. 2010 ;15(1):15-20. doi:.
Demir C, Altıntaş A, Paşa S, et al. Assessment of patients with thrombotic thrombocytopenic purpura. Eastern J Med. 2010;15(1):15-20. doi:.
Demir, Cengiz et al. "Assessment of patients with thrombotic thrombocytopenic purpura." Eastern J Med vol. 15,1 (2010): 15-20. doi:.
Demir, Cengiz, Abdullah Altıntaş, Semir Paşa, M. Ali Kaplan, Yüksel Küçükzeybek and Orhan Ayyıldız "Assessment of patients with thrombotic thrombocytopenic purpura." Eastern J Med 15, no. 1 (2010): 15-20. https://doi.org/.
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