Primary spinal cord tumors represent 2%10% of all central nervous system tumors and mainly comprise astrocytoma, ependymoma, ganglioglioma, oligodendroglioma and subependymoma. Only 1%3% of all spinal cord tumors show primary glioblastoma multiforme pathology.Spinal glioblastoma multiforme was diagnosed as a result of MRI findings of the patient (The thoracic spinal MR revealed an intramedullary nodular expansile lesion), who had numbness in lower extremities. Maximum safe resection was performed our patient. The lesion reported as GBM. Adjuvant radiotherapy and chemotherapy including temozolomide was applied subsequently. The primary treatment of spinal glioblastoma multiforme includes surgery, radiotherapy and chemotherapy. Despite multidisciplinary approaches available to treat spinal glioblastoma multiforme, the prognosis remains poor, with survival rates of 1012 months. Total resection is nevertheless the main therapy for spinal glioblastoma multiforme in spite of current developments. Although spinal intramedullary glioblastoma multiforme particularly is quite rare, its treatment is very difficult.Keywords: Intramedullary tumor, Glioblastoma multiforme, Spinal cord; thoracic, Radiotherapy.