Combined factor V and factor VIII deficiency: the report of two cases

Combined FV and FVIII deficiency is a rarely seen hereditary coagulation disease. Here, we presented two cases diagnosed with combined FV and FVIII deficiency. Factor V levels were 12% and 3% and FVIII levels were 7% and 2%, respectively. For both cases, prothrombin time and activated partial thromboplastin time were prolonged. The first case presented with nasal bleeding while the second case was diagnosed with an abdominal hemorrhage. These cases make us remember that when a hereditary bleeding disorder is considered in the presence of simultaneous prolongation of PT and aPTT, the possibility of combined FV and FVIII deficiency should be considered, although it is seen very rarely.