ISSN 1301 - 0883 / E-ISSN 1309 - 3886
 
 








  Beta-Fibrinogen 455 G/A and Angiotensin Converting Enzyme Ins/Del Polymorphisms In Patients With Lung Cancer [Eastern J Med]
Eastern J Med. 2018; 23(3): 160-167 | DOI: 10.5505/ejm.2018.91885  

Beta-Fibrinogen 455 G/A and Angiotensin Converting Enzyme Ins/Del Polymorphisms In Patients With Lung Cancer

Hamit Hakan Alp1, Fatma Zuhal Umudum2, Ebubekir Bakan2
1Department Of Biochemistry, Faculty Of Medicine, Yüzüncü Yıl University, Van, Turkey
2Department Of Biochemistry, Faculty Of Medicine, Atatürk University, Erzurum, Turkey

INTRODUCTION: In our study we have investigated polymorphism due to base change occurring at -455 position of promoter region of β-fibrinogen synthesizing gene in lung cancer patients. In addition, we have also investigated insertion/deletion (I/D) polymorphism in intron 16 of Angiotensin Converting Enzyme (ACE) gene, located on chromosome 17q23. Aim of our study is to determine polymorphisms of β-fibrinogen -455 G/A and ACE I/D in patients with lung cancer and healthy control and to determine whether these polymorphisms contribute to the formation of lung cancer. In addition, we aimed to clarify whether β-fibrinogen -455 G/A polymorphism effect the level of fibrinogen synthesis in patients with lung cancer.
METHODS: Samples in our study was obtained from 100 patients with lung cancer and 100 healthy volunteers. Plasma fibrinogen levels were measured with ELISA method. Polymorphism analyses were determined with PCR-reverse hybridization method.
RESULTS: Results of our study revealed that fibrinogen levels of patients with lung cancer were significantly higher than healthy control group (p<0.01). No difference was determined for β-fibrinogen -455 G/A and ACE I/D polymorphisms between patients with lung cancer and healthy control group. In both of the groups fibrinogen level was higher in AA genotype compared to GG and GA genotypes in both of the groups (p<0.05)
DISCUSSION AND CONCLUSION: As a result, it can be stated that β-fibrinogen -455 G/A and ACE I/D polymorphisms are not related with formation and prognosis of lung cancer.

Keywords: Lung cancer, ACE I/D, β,,, -fibrinogen -455 G/A, polymorphism


Hamit Hakan Alp, Fatma Zuhal Umudum, Ebubekir Bakan. Beta-Fibrinogen 455 G/A and Angiotensin Converting Enzyme Ins/Del Polymorphisms In Patients With Lung Cancer. Eastern J Med. 2018; 23(3): 160-167

Corresponding Author: Hamit Hakan Alp, Türkiye


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