ISSN 1301 - 0883 | E-ISSN: 1309-3886
Relationship between SUVmax of 18F-FDG PET/CT and serum YKL-40 levels in breast cancer [Eastern J Med]
Eastern J Med. 2022; 27(1): 77-83 | DOI: 10.5505/ejm.2022.79027

Relationship between SUVmax of 18F-FDG PET/CT and serum YKL-40 levels in breast cancer

Ebru Orsal Ibisoglu1, Arif Kürşad Ayan2, Zeynep Akar3, Engin şebin4
1Department Of Nuclear Medicine, Göztepe Prof Dr Süleyman Yalçın City Hospital, Istanbul, Turkey
2Department of Nuclear Medicine, Yucelen Mugla Hospital, Mugla, Turkey
3Department Of Nuclear Medicine, Atatürk City Hospital, Balıkesir, Turkey.
4Department Of Biochemistry, University Of Health Sciences, Erzurum Regional Training And Research Hospital, Erzurum, Turkey

INTRODUCTION: This investigation aimed to study the differences in tumor maximum standardized uptake values (SUVmax) in breast cancer patients and compare serum levels of YKL-40, an inflammatory glycoprotein found at high levels in patients with different types of cancer, with healthy controls.
METHODS: Fifty-one women who underwent 18F-fluorodeoxyglucose (FDG) positron emission tomography-computed tomography (PET/CT) imaging for the staging of pathologically-confirmed breast cancer were included. The tumor SUVmax of each patient was calculated by 18F-FDG PET/CT. Serum YKL-40, ischemia modified albumin (IMA), carcinoembryonic antigen (CEA), and cancer antigen 15-3 (CA15-3) levels were assessed.. A group of 38 healthy women were included as controls, from which serum YKL-40 and IMA levels were obtained.
RESULTS: Compared to healthy subjects, serum YKL-40 and IMA levels were significantly higher in patients with breast cancer (p<0.001 for both). Patients with a tumor size of 2-5 cm had significantly higher YKL-40 (p=0.002), SUVmax (p=0.008), CEA (p=0.025), and CA15-3 (p=0.016) measurements than patients with a tumor size of <2 cm. However, IMA levels did not vary (p>0.05) between the two groups of tumor sizes. While YKL-40 showed significant correlations with CA15-3 (r=0.318, p=0.023) and IMA (r=0.257, p=0.016), no correlation was found between SUVmax and the measured serum variables in the breast cancer group (p>0.05).

DISCUSSION AND CONCLUSION: Our results indicate that serum IMA and YKL-40 levels were above average in breast cancer patients. Also, increasing SUVmax and serum YKL-40 levels may be separately observed related to tumor size. YKL-40 and SUVmax may be utilized in the evaluation and follow-up of breast cancer.

Keywords: Breast Cancer, PET/CT, Chitinase-3-Like Protein 1, YKL-40 Protein

Ebru Orsal Ibisoglu, Arif Kürşad Ayan, Zeynep Akar, Engin şebin. Relationship between SUVmax of 18F-FDG PET/CT and serum YKL-40 levels in breast cancer. Eastern J Med. 2022; 27(1): 77-83

Corresponding Author: Ebru Orsal Ibisoglu, Türkiye
Manuscript Language: English
LookUs & Online Makale