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Eastern J Med. 2017; 22(2): 70-73 | DOI: 10.5505/ejm.2017.76486
2Department Of Otorhinolaryngology-head And Neck Surgery Faculty Of Medicine, Universiti Teknologi Malaysia, Selangor, Malaysia
3Neurosurgery Unit, Department Of Surgery Faculty Of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Epstein-Barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: A distinct entity
Farah Dayana Zahedi1, Nik Mohd Hazleigh Nik Hussin2, Salina Husain1, Ramesh Kumar3, Balwant Singh Gendeh11Department Of Otorhinolaryngology-head And Neck Surgery Faculty Of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia2Department Of Otorhinolaryngology-head And Neck Surgery Faculty Of Medicine, Universiti Teknologi Malaysia, Selangor, Malaysia
3Neurosurgery Unit, Department Of Surgery Faculty Of Medicine, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Introduction: Primary sinonasal nasopharyngeal-type undifferentiated carcinoma (PSNPC) is a rare variant of the sinonasal undifferentiated carcinoma (SNUC). The histological classification has implications on its management.
Case report: We report a case of a 32 year old lady who presented with progressive nasal obstruction due to a sinonasal tumour. Endoscopic excisionwas performed and histopathologicall examination confirmedPSNPC with positive Epstein Barr virus insitu hybridisation.
Conclusion: Identification and recognition of PSNPC as a separate clinicopathological entity from SNUC is important as it dictates the management of this rare variant. Immunohistochemical analysis is invaluable in this endeavor.
Farah Dayana Zahedi, Nik Mohd Hazleigh Nik Hussin, Salina Husain, Ramesh Kumar, Balwant Singh Gendeh. Epstein-Barr virus positive primary sinonasal nasopharyngeal-type undifferentiated carcinoma: A distinct entity. Eastern J Med. 2017; 22(2): 70-73
Corresponding Author: Farah Dayana Zahedi, Malaysia
Manuscript Language: English
Corresponding Author: Farah Dayana Zahedi, Malaysia
Manuscript Language: English