ISSN 1301 - 0883 / E-ISSN 1309 - 3886
 
 








  Thiol/Disulphide homeostasis and oxidative stress in patients with peripheral facial paralysis [Eastern J Med]
Eastern J Med. 2018; 23(3): 206-212 | DOI: 10.5505/ejm.2018.62533  

Thiol/Disulphide homeostasis and oxidative stress in patients with peripheral facial paralysis

Canser Yilmaz DEMIR1, Nazim BOZAN2, Omer Faruk KOCAK1, Erdem COKLUK3, Yilmaz SULTANOGLU1, Muhammet Eren ERSOZ1
1Department of Plastic and Reconstructive Surgery, Van Yuzuncu Yıl University Faculty of Medicine
2Department of Otorhinolaryngology, Van Yuzuncu Yıl University Faculty of Medicine
3Department of Biochemistry, Van Yuzuncu Yıl University Faculty of Medicine

INTRODUCTION: The main pathophysiological mechanism responsible from the peripheral facial paralysis (PFP) is the ischemia, inflammation and swelling of the facial nerve. The purpose of the present study was to assess the oxidative stress parameters including the thiol/disulphide homeostasis in patients with peripheral facial paralysis.
METHODS: A total of 32 patients with PFP and 32 healthy controls were recruited in this cross-sectional study. Serum samples were compared for thiol/disulphide homeostasis (TDH), total oxidant status (TOS), total antioxidant capacity (TAC), paraoxonase (PON), stimulated paraoxonase (SPON), arylesterase (ARES), ceruloplasmin (CLP), myeloperoxidase (MPO), and catalase (CAT) levels.
RESULTS: There were no significant differences between PFP patients and the control group regarding age and gender distribution. Remarkably, TOS (p=0.034), CAT (p<0.001), ARES (p<0.001), native thiol (p<0.001), total thiol (p<0.001), and native thiol/total thiol ratio (p<0.001) were significantly higher in the control group. In contrast, serum ceruloplasmin level (p=0.005) as well as disulphide/native thiol (%) (p=0.001) and disulphide/total thiol (%) (p<0.001) ratios were found to be higher in PFP patients compared to the control group.
DISCUSSION AND CONCLUSION: Thiol/disulphide homeostasis that was suggested as a useful indicator of oxidant/antioxidant imbalance may be a practical marker in diagnosis and follow-up of PFP. Further studies are warranted to determine the effects of nutritional and therapeutic approaches for normalization of oxidative stress in treatment and prevention of PFP.

Keywords: homeostasis, oxidative stress, peripheral facial paralysis, thiol/disulphide.


Canser Yilmaz DEMIR, Nazim BOZAN, Omer Faruk KOCAK, Erdem COKLUK, Yilmaz SULTANOGLU, Muhammet Eren ERSOZ. Thiol/Disulphide homeostasis and oxidative stress in patients with peripheral facial paralysis. Eastern J Med. 2018; 23(3): 206-212

Corresponding Author: Canser Yilmaz DEMIR, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 
Copyright © 2020 Eastern Journal of Medicine. All Rights Reserved.
Home        |        Contact
LookUs & OnlineMakale