Can Platelet Mass Index be used as a prognostic marker in the diagnosis of missed abortion patients?

INTRODUCTION: The aim of this study is to evaluate the effectiveness of PCT (Platelet crit), NLR (Neutrophil-to-lymphocyte ratio), and PMI (Platelet Mass Index), which are among the complete blood count parameters, in predicting missed abortion (MA).
METHODS: The case-control study was conducted between January 1, 2020, and January 2022. A total of 926 pregnant women, including 474 MA and 452 normal patients, were included in the study.
RESULTS: There were no significant differences between the patient and control groups in terms of age, gestational week, body mass index (BMI), gravida and parity, and thyroid functions (p>0.05). PMI, PCT, and NLR values were significantly higher in the MA group (p<0.05). While there was a strong positive relationship between PMI and PCT, there was a negative relationship between PMI and NLR (p<0.05). In the ROC analysis, PCT>0.24, NLR>2.99, and PMI>2430.9 were significantly associated with an increased risk of missed abortion (P<0.05). Logistic regression analysis revealed that a one-unit increase in PCT resulted in a statistically significant 3.41-fold increase in the risk of missed abortion, a one-unit increase in NLR resulted in a 2.56-fold increase, and a one-unit increase in PMI resulted in a 1.004-fold increase (p< 0.05).
DISCUSSION AND CONCLUSION: We think that PMI, NLR, and PCT values obtained from complete blood count parameters are important predictors of missed abortion