ISSN 1301 - 0883 / E-ISSN 1309 - 3886
 
 








  The effect of moclobemide, reversible inhibitor of monoamine oxidase-A, on the ethanolized rat brain [Eastern J Med]
Eastern J Med. 1998; 3(1): 20-23

The effect of moclobemide, reversible inhibitor of monoamine oxidase-A, on the ethanolized rat brain

E. Karaöz1, M. Kanter2, Z. Başçı3, V. Köksal4
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Objective This experiment was carried out to demonstrate the effect of moclobemide on ethanolized rat brain. Method Thirty male rats, 20-25 g and 20 days old, were used. Rats were fed with a diet (milk) containing ethanol (10%) in ethanol-only treated group and were moclobemide injected (30 mg/kg) in ethanol+moclobemide treated group daily for 21 days. Results It was found that serum ethanol level in ethanol+moclobemide treated group was significantly higher than in ethanol-only treated group at the end of the experiment. Electron microscopic examination revealed more prominent neurotoxicity in ethanol+moclobemide treated group than in ethanol-only treated group. Conclusion We concluded that moclobemide decreased the elimination of ethanol. However, more studies are needed to demonstrate its mechanism.

Keywords: Ethanol, moclobemide, brain, toxicity, electron microscope.


E. Karaöz, M. Kanter, Z. Başçı, V. Köksal.  The effect of moclobemide, reversible inhibitor of monoamine oxidase-A, on the ethanolized rat brain. Eastern J Med. 1998; 3(1): 20-23


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