The effect of moclobemide, reversible inhibitor of monoamine oxidase-A, on the ethanolized rat brain

Objective This experiment was carried out to demonstrate the effect of moclobemide on ethanolized rat brain. Method Thirty male rats, 20-25 g and 20 days old, were used. Rats were fed with a diet (milk) containing ethanol (10%) in ethanol-only treated group and were moclobemide injected (30 mg/kg) in ethanol+moclobemide treated group daily for 21 days. Results It was found that serum ethanol level in ethanol+moclobemide treated group was significantly higher than in ethanol-only treated group at the end of the experiment. Electron microscopic examination revealed more prominent neurotoxicity in ethanol+moclobemide treated group than in ethanol-only treated group. Conclusion We concluded that moclobemide decreased the elimination of ethanol. However, more studies are needed to demonstrate its mechanism.