ISSN 1301 - 0883 | E-ISSN: 2687-5101
Effects of Parenteral Glutamine Supplementation on Endocan Levels in Septic Patients [Eastern J Med]
Eastern J Med. 2021; 26(1): 157-164 | DOI: 10.5505/ejm.2021.25986

Effects of Parenteral Glutamine Supplementation on Endocan Levels in Septic Patients

Basak Kilic1, Hulya Cicek2, ayşe özlem mete3, Suleyman Ganidagli4, Berna KAYA UGUR4
1Gaziantep Ersin Arslan Training Hospital, Department of Anesthesiology and Reanimation, Gaziantep, TURKEY
2Gaziantep University, Faculty of Medicine, Department of Biochemistry, Gaziantep, TURKEY
3Gaziantep University, Faculty of Medicine, Department of Infectious Diseases, Gaziantep, TURKEY
4Gaziantep University, Faculty of Medicine, Department of Anesthesiology and Reanimation, Gaziantep, TURKEY

INTRODUCTION: The purpose of this study was to investigate the effect of parenteral Glutamine (Gln) supplementation on Endocan levels in patients with sepsis receiving parenteral nutrition.
METHODS: A total of 60 patients with a diagnosis of sepsis were enrolled to the study. Patients were randomly divided into two groups to receive either standard parenteral nutrition or standard parenteral nutrition plus the parenteral dipeptide Gln-Ala. The Gln-Ala dipeptide dosage was calculated to be 0.35 mg / kg. Demographic data, CRP, ESR, lactate, WBC, Endocan serum levels, APACHE II scores at admission to ICU, and SOFA scores at day 0, 3rd and 7th days were all recorded. The outcomes of the patients were also recorded after 28-day follow up.
RESULTS: There was no statistically significant difference between the Endocan values of patients receiving parenteral dipeptide Gln-Ala plus the standard parenteral nutrition vs standard parenteral nutrition. Also, there was no significant difference in mortality and septic shock development rates between the two groups.
DISCUSSION AND CONCLUSION: According to our results, there was not a significant difference regarding outcomes of the patients in both study groups, including mortality rates and there was no beneficial effect of indiscriminate GLN supplementation. Further prospective studies with larger sample size are needed in order to make conclusive comments that there is no beneficial effect of administering GLN.

Keywords: Endocan, Glutamine, Parenteral Nutrition, Sepsis-3

Basak Kilic, Hulya Cicek, ayşe özlem mete, Suleyman Ganidagli, Berna KAYA UGUR. Effects of Parenteral Glutamine Supplementation on Endocan Levels in Septic Patients. Eastern J Med. 2021; 26(1): 157-164

Corresponding Author: Berna KAYA UGUR, Türkiye
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