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Use of Contractubex® (Allantoin, Heparin, Extractum Cepae) to Prevent Scar Formation in The Rabbits to Which Primary Closure has been Applied After Urethrotomy [Eastern J Med]
Eastern J Med. 2020; 25(1): 161-169 | DOI: 10.5505/ejm.2020.80948  

Use of Contractubex® (Allantoin, Heparin, Extractum Cepae) to Prevent Scar Formation in The Rabbits to Which Primary Closure has been Applied After Urethrotomy

KEMAL AYENGİN1, Nizamettin Kılıç2
1Yuzuncu Yil University, Medical School, Department Of Pediatric Surgery, Van, Turkey
2Uludag University, Medical School, Departments Of Pediatric Surgery And Pediatric Urology, Bursa, Turkey.

INTRODUCTION: The scar tissue occurring in operating area after the repair of hypospadias which is one of the common congenital anomalies of male children has part in formation of post operative complications. Many surgical techniques and materials have been used to reduce complications. The purpose of this study is to research the effects of contractubex® (allantoin, heparin, extractum cepae [AHEC]) gel on development of scar in the area repaired after urethrotomy.
METHODS: In the study, 45 male White New Zealand rabbits were used. The rabbits were divided into three groups randomly.
Group 1(K): The group to which urethrotomy and primary closure were applied
Group 2(A): The group to which urethrotomy, primary closure + 15-day AHEC were applied
Group 3(B): The group to which urethrotomy, primary closure + 30-day AHEC were applied
Urethras of the rabbits in the groups were calibrated with angiocath (24 Fr) once a day for 30 days. Along with calibration, AHEC was applied to the urethras of the rabbits in 2nd group for 15 days and urethras of the rabbits in the 3rd group for 30 days. To evaluate scar tissue, macroscopic and histopathological evaluations were carried out.

RESULTS: Although inflammation was much more in the groups to which AHEC was applied, fibrosis was determined to be less.
DISCUSSION AND CONCLUSION: It is thought that the application of AHEC may be effective in reducing scar formation after operation.

Keywords: Hypospadias, Allantoin, Heparin, Extractum Cepae.


KEMAL AYENGİN, Nizamettin Kılıç. Use of Contractubex® (Allantoin, Heparin, Extractum Cepae) to Prevent Scar Formation in The Rabbits to Which Primary Closure has been Applied After Urethrotomy. Eastern J Med. 2020; 25(1): 161-169

Corresponding Author: KEMAL AYENGİN, Türkiye


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