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Determination of Lethal Doses of Volatile and Fixed Oils of Several Plants [Eastern J Med]
Eastern J Med. 2004; 9(1): 4-6

Determination of Lethal Doses of Volatile and Fixed Oils of Several Plants

Hanefi Özbek1, Mustafa Öztürk2, Abdurrahman Öztürk0, Ebubekir Ceylan0, Zabit Yener0
1
2

To determine lethal doses of fixed and/or volatile oils extracted from leafs or fruits of Pimpinella anisum, Foeniculum vulgare, Sesamum indicum, Eugenia caryophyllata, Nigella sativa, Urtica pilulifera, Apium graveolens, Cuminum cyminum, Coriandrum sativum and Thymus fallax. Method: Swiss albino mice were injected intraperitoneally with different concentrations of the extract and results were evaluated with the method of probit analysis. Results: Maximum volume of oil administered to mice was kept below 0.5 ml. The oils of Sesamum indicum and Urtica pilulifera was completely non-lethal even at doses reaching 12.8 ml/kg and considered non-toxic. Conclusion: Lethal doses were determined for all other plants and LD1, LD10, LD50, LD90 and LD99 values were given.

Keywords: Volatile oil, fixed oil, lethal doses, plants


Hanefi Özbek, Mustafa Öztürk, Abdurrahman Öztürk, Ebubekir Ceylan, Zabit Yener. Determination of Lethal Doses of Volatile and Fixed Oils of Several Plants. Eastern J Med. 2004; 9(1): 4-6


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