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Evaluation of antimalarial potential of aqueous stem bark extract of Bombax buonopozense P. Beauv. (Bombacaceae) [Eastern J Med]
Eastern J Med. 2012; 17(2): 72-77

Evaluation of antimalarial potential of aqueous stem bark extract of Bombax buonopozense P. Beauv. (Bombacaceae)

Tom Chinyere Iwuanyanwu1, Godwin Christian Akuodor2, AugustineDick Essien3, Florence Chidume Nwinyi4, Joseph Linus Akpan5, Dorcas Okayo Okorafor6
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The treatment of malaria in Africa is becoming increasingly difficult due to rising prevalence of plasmodium falciparum resistant to antimalarial drugs. This study was undertaken to investigate the in vivo antiplasmodial effect of the aqueous stem bark extract of Bombax buonopozense in mice infected with chloroquine-sensitive plasmodium berghei NK65. The in vivo antiplasmodial effect against early infection and curative effect against established infection were studied. The extract at all doses (100, 200 and 400 mg/kg, p.o.) used, exhibited significant (P<0.05), dose-dependent activity against the parasite in suppressive and curative tests. These results show that the stem bark extract of Bombax buonopozense plant has significant antiplasmodial effect. The reduction in parasitemia levels in the two employed models suggest that a part of its antimalarial activity is mediated by direct plasmocidal effect on the parasite.

Keywords: Antimalaria, bombax buonopozense, medicinal plant, mice, plasmodium berghei


Tom Chinyere Iwuanyanwu, Godwin Christian Akuodor, AugustineDick Essien, Florence Chidume Nwinyi, Joseph Linus Akpan, Dorcas Okayo Okorafor. Evaluation of antimalarial potential of aqueous stem bark extract of Bombax buonopozense P. Beauv. (Bombacaceae). Eastern J Med. 2012; 17(2): 72-77


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