ISSN 1301 - 0883 / E-ISSN 1309 - 3886
 
 







 
 
Search





Retrospective Evaluation of Patients with Hairy Cell Leukemia: A Decade Experience at a Single Center [Eastern J Med]
Eastern J Med. 2019; 24(4): 437-440 | DOI: 10.5505/ejm.2019.67944  

Retrospective Evaluation of Patients with Hairy Cell Leukemia: A Decade Experience at a Single Center

Mehmet Baysal1, volkan bas1, sedanur karaman gülsaran1, ALİ CANER OZDOVER1, Elif Umit1, Hakki Onur Kirkizlar1, Fulya Oz Puyan2, Ahmet Muzaffer Demir1
1Trakya University Faculty of Medicine, Department of Hematology, Edirne, Turkey
2Trakya University Faculty of Medicine, Department of Pathology, Edirne, Turkey

INTRODUCTION: In this study, we aimed to investigate the demographic characteristics, treatment modalities and response rates in patients with Hairy Cell Leukemia (HCL) which have been diagnosed and followed up in our center.
METHODS: Data of the 27 patients diagnosed with HCL at our center between 2007 and 2018 were retrospectively evaluated. Patients diagnosed with HCL according to WHO 2016 classification of lymphoid neoplasms by bone marrow biopsy. Flow cytometry, clinical and demographic data of the patients were evaluated. BRAFV600E mutational status evaluated in selected cases. All patients were given cladribine as first line treatment
RESULTS: Eight of our patients (29.6%) were female and 19 (70.3%) were male. In 20 patients (74%), complete remission was detected with first-line cladribine treatment, while in 3 patients (11.1%) partial remission was achieved, and 4 patients (14.8%) were unresponsive. Rituximab was administered to 3 refractory patients while one patient received pentostatine. Two patients who could not achieve remission died due to severe and critical infection, while one patient died due to cerebrovascular disease. 24 of our patients are still alive.
DISCUSSION AND CONCLUSION: Cladribine confers a safe and effective treatment modality. Although purine analogs have improved response rates and progression-free survival, progress has yet to be made for resistant and relapsing patients

Keywords: Hairy Cell Leukemia, Cladribine, Real World Data


Mehmet Baysal, volkan bas, sedanur karaman gülsaran, ALİ CANER OZDOVER, Elif Umit, Hakki Onur Kirkizlar, Fulya Oz Puyan, Ahmet Muzaffer Demir. Retrospective Evaluation of Patients with Hairy Cell Leukemia: A Decade Experience at a Single Center. Eastern J Med. 2019; 24(4): 437-440

Corresponding Author: Mehmet Baysal, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 
Copyright © 2019 Eastern Journal of Medicine. All Rights Reserved.
Home        |        Contact
LookUs & OnlineMakale