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Lmyphocytic subpopulations in the exacerbations of respiratory tract infections of patients with COPD [Eastern J Med]
Eastern J Med. 1999; 4(1): 20-22

Lmyphocytic subpopulations in the exacerbations of respiratory tract infections of patients with COPD

R. Dodurgalı1, F. Şahin1, H. Can1, S. Öztürk1, F. Atabey1, A. Şentürk1, A. Poluman1

Objective Peripheral blood T lymphocyte subpopulations of patients with chronic obstructive pulmonary disease (COPD) hospitalized at the 3rd clinic of Yedikule Thoracic Diseases Hospital with a clinical picture of respiratory tract infection were measured. Method Measurements were performed by flow cytometric method. CD4, CD8, CD4/CD8 results were compared with values accepted to be normal by employing student-t test. Results Ten of our cases (76.9%) possessed a CD4 percentage of over normal value. Median value was found to be 36.43. In 11 of our cases (84.6%) a CD8 percentage of over normal value was detected. Median value was 31.45. Ten of our cases (76.9%) had a CD4/CD8 value of over normal. Median value was 1.07. CD4 levels and percentages of our patients with COPD were found to be significantly high at p= 0.039 level compared to normals. CD8 percentages, however were found to be significantly high at p=0.001 compared to normals, whereas CD4/CD8 ratio did not manifest any significance compared to normals. Conclusion Our findings determined the increase in T cells following antigenic stimulus in exacerbation of respiratory tract infections in patients with COPD.

Keywords: Lymphocytic subpopulations, exacerbation, COPD.


R. Dodurgalı, F. Şahin, H. Can, S. Öztürk, F. Atabey, A. Şentürk, A. Poluman. Lmyphocytic subpopulations in the exacerbations of respiratory tract infections of patients with COPD. Eastern J Med. 1999; 4(1): 20-22


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