ISSN 1301 - 0883 / E-ISSN 1309 - 3886

  Assessment of PTCH1a promoter methylation in BCC carcinogenesis [Eastern J Med]
Eastern J Med. 2014; 19(2): 105-106

Assessment of PTCH1a promoter methylation in BCC carcinogenesis

D. Beyza Sayżn Kocakap1

Basal Cell Carcinoma (BCC) is the most common cancer in humans. It is known that PTCH1 mutations in Sonic Hedgehog pathway play significant role in BCC pathogenesis. However PTCH1 (Patched) inactivation through promoter methylation is still under investigation. In this study, promoter methylation of the PTCH1 gene was analysed by Combined Bisulphite Restriction Analysis in 10 formalin-fixed paraffin-embedded (FFPE) BCC tissues. There was no methylation in any of the samples. Results suggest that PTCH1 promoter methylation is not effective in BCC carcinogenesis and FFPE tissues are not suitable for methylation analysis since 44 specimens were included in the study and only 10 of them gave result.

Keywords: Basal Cell Carcinoma, PTCH1, methylation, COBRA

D. Beyza Sayżn Kocakap. Assessment of PTCH1a promoter methylation in BCC carcinogenesis. Eastern J Med. 2014; 19(2): 105-106

Full Text PDF
Download citation
Reference Manager
Share with email

Similar articles
Google Scholar

Copyright © 2020 Eastern Journal of Medicine. All Rights Reserved.
Home        |        Contact
LookUs & OnlineMakale