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Pulmonary adenocarcinoma presented with Lambert- Eaton myasthenic syndrome [Eastern J Med]
Eastern J Med. 2019; 24(3): 386-389 | DOI: 10.5505/ejm.2019.58855  

Pulmonary adenocarcinoma presented with Lambert- Eaton myasthenic syndrome

Fettah Eren1, Recep Aygul2, Serefnur Ozturk2
1University of Health Sciences, Konya Training And Research Hospital, Neurology Clinic, Konya, Turkey
2Selcuk University Faculty of Medicine, Department of Neurology, Konya, Turkey

Paraneoplastic neurological syndrome is an autoimmune disease caused by distant effect of tumor. Lambert- Eaton myasthenic syndrome (LEMS) is a paraneoplastic disease that is associated with voltage-dependent calcium channel antibodies. These autoantibodies affect especially presynaptic neuromuscular area. A 65-year-old male patient admitted to hospital with the complaint of difficulty in walking and climbing stairs. LEMS was considered with clinical examination and electrophysiological assessment. The diagnosis of lung adenocarcinoma was done by thoracic computed tomography and bronchoscopic biopsy. LEMS is especially associated with small cell lung cancer. It is rarely associated with lung adenocarcinoma like this patient. In the electrophysiological anlyses; significant amplitude increment is diagnostic with high frequency tetanic stimulation.

Keywords: Lambert-Eaton myasthenic syndrome, adenocarcinoma, electrophysiology


Fettah Eren, Recep Aygul, Serefnur Ozturk. Pulmonary adenocarcinoma presented with Lambert- Eaton myasthenic syndrome. Eastern J Med. 2019; 24(3): 386-389

Corresponding Author: Fettah Eren, Türkiye


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